NF-κB is important in regulating cellular responses because it belongs to the category of "rapid-acting" primary transcription factors, i.e., transcription factors that are present in cells in an inactive state and do not require new protein synthesis in order to become activated (other members of this family include transcription factors such as c-Jun, STATs, and nuclear hormone receptors). This allows NF-κB to be a first responder to harmful cellular stimuli. Known inducers of NF-κB activity are highly variable and include reactive oxygen species (ROS), tumor necrosis factor alpha (TNFα), interleukin 1-beta (IL-1β), bacterial lipopolysaccharides (LPS), isoproterenol, cocaine, and ionizing radiation.
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MoreBisoprolol是β1肾上腺素受体阻断剂。
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MoreDexmedetomidine 是α2肾上腺素受体激动剂,有止痛镇静活性。
MoreFormoterol Fumarate是长效的β2-肾上腺素受体激动剂。
MorePropranolol HCl
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