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Dexmedetomidine HCl

盐酸右美托咪定 盐酸右美托咪定; (+)-Medetomidine hydrochloride; (S)-Medetomidine hydrochloride

Dexmedetomidine 是α2肾上腺素受体激动剂，有止痛镇静活性。

目录号
EY0922
EY0922
EY0922
纯度
99.36%
99.36%
99.36%
规格
5 mg
10 mg
50 mg
原价
368
520
1680
售价
368
520
1680
库存
现货
现货
现货
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  • 生物活性

    Dexmedetomidine HCl is a highly selective and potent alpha-2 adrenoceptor agonist, which reduces anesthetic requirements for patients by providing significant sedation.

  • 体外研究

  • 体内研究

  • 激酶实验

  • 细胞实验

  • 动物实验

  • 不同实验动物依据体表面积的等效剂量转换表（数据来源于FDA指南）

    动物 A (mg/kg) = 动物 B (mg/kg)×动物 B的Km系数/动物 A的Km系数


    例如，已知某工具药用于小鼠的剂量为88 mg/kg , 则用于大鼠的剂量换算方法：将88 mg/kg 乘以小鼠的Km系数（3），再除以大鼠的Km系数（6），得到该药物用于大鼠的等效剂量44 mg/kg。

  • 参考文献

    [1] Roman Řemínek et. Al. Electrophoresis, 36(11-12), 1349-1357 (2015).
    [2] Allan D Rasmussen et. Al. Experimental and Toxicologic Pathology, 67(1), 13-20 (2015).
    [3] J L Adolphe et. Al. Journal of Animal Physiology and Animal Nutrition, 99(4), 767-776 (2015).

    分子式
    C13H17ClN2    		 分子量
    236.74    		 CAS号
    145108-58-3    		 储存方式
    ﹣20 ℃冷藏长期储存。冰袋运输
    溶剂（常温）
    		 DMSO
    48 mg/mL    		 Water
    <1 mg/mL    		 Ethanol
    48 mg/mL

    体内溶解度

  • Clinical Trial Information ( data from http://clinicaltrials.gov )

    NCT Number Conditions Interventions Sponsor/Collaborators Phases Start Date Last Updated
    NCT02327156 Vitreoretinal Surgery Under Sub-Tenon's Anesthesia Drug: dexmedetomidine Magrabi Eye & Ear Hospital Phase 3 2014-01-01 2014-12-29
    NCT01498380 Hemodynamic Instability Drug: Dexmedetomidine University of British Columbia 2012-01-01 2014-02-05
    NCT02566863 Haemodynamic Effects of Dexmedetomidine Drug: Dexmedetomidine Medical University of Gdansk Phase 4 2015-06-01 2017-03-21
    NCT02187068 Obesity Drug: Dexmedetomidine Pontificia Universidad Catolica de Chile Phase 4 2012-04-01 2014-07-07
    NCT02557867 Obesity Drug: Dexmedetomidine Pontificia Universidad Catolica de Chile Phase 4 2015-08-01 2016-10-10
    NCT02529202 Hypoxic-ischemic Encephalopathy Drug: Dexmedetomidine Seattle Children's Hospital Early Phase 1 2016-03-01 2017-01-10
    NCT01485380 Dexmedetomidine Induced Sedation Drug: dexmedetomidine Massachusetts General Hospital 2012-09-01 2016-06-20
    NCT01976754 Sepsis|Agitation Drug: Dexmedetomidine First Affiliated Hospital of Zhejiang University 2013-09-01 2013-10-30
    NCT01900405 Traumatic Brain Injury|Children Drug: Dexmedetomidine University of Sao Paulo|Boston Children Hospital 2013-04-01 2013-07-11
    NCT03091894 Dexmedetomidine Drug: Propofol|Drug: Dexmedetomidine Essam Fathi|Zagazig University 2017-04-01 2017-03-21
    NCT02715154 Cesarean Section, Affecting Fetus or Newborn Drug: Dexmedetomidine|Drug: Placebo The First Affiliated Hospital with Nanjing Medical University Phase 1 2015-06-01 2016-03-21
    NCT02108171 Benign Neoplasm of Vocal Fold - Glottis Drug: Dexmedetomidine|Drug: placebo Guangzhou First Municipal People Hospital 2014-03-01 2016-02-13
    NCT02155010 Blood Pressure|Anxiety Drug: Dexmedetomidine|Drug: Dexmedetomidine with heavy bupivacaine Inje University 2014-03-01 2016-08-03
    NCT00345384 Post-operative Pain|Respiratory Depression Drug: Dexmedetomidine|Other: Placebo (Normal Saline) Baylor Research Institute Phase 1|Phase 2 2008-05-01 2016-01-12
    NCT00573066 Hypoplastic Left Heart|Tetralogy of Fallot|Tricuspid Atresia Drug: Dexmedetomidine Athena Zuppa|Children's Hospital of Philadelphia Phase 1 2004-05-01 2013-02-28
    NCT02299232 Anesthesia Drug: Dexmedetomidine Sisli Etfal Training & Research Hospital Phase 4 2014-02-01 2014-11-19
    NCT01116700 Seizure Disorders Drug: Dexmedetomidine University of California, San Francisco Phase 1 2010-12-01 2013-08-06
    NCT01864187 Obesity Drug: Dexmedetomidine Guangzhou General Hospital of Guangzhou Military Command Phase 4 2013-06-01 2015-03-11
    NCT02459509 Anxiety, Separation Drug: Dexmedetomidine The University of Hong Kong Phase 4 2015-06-01 2016-04-15
    NCT00576381 Tetrology of Fallot|Heart Ventricle|Hypoplastic Left Heart Drug: Dexmedetomidine Athena Zuppa|Children's Hospital of Philadelphia Phase 1 2006-04-01 2013-04-10

    注：以上所有数据均来自公开文献，并不保证对所有实验均有效，数据仅供参考。

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