MK-886 is an inhibitor of leukotriene biosynthesis, inhibiting 5-lipoxygenase-activating protein (FLAP). It is also a moderately potent PPARα antagonist.
MoreNxt629 is an effective, selective and competitive PPAR- α Antagonists, human PPAR α The IC50 value of is 77 nm, which is more selective than other nuclear hormone receptors, such as ppar δ, PPAR γ, Er β, GR and tr β, IC50 values are 6.0, 15, 15.2, 32.5 and >100 respectively μ M。
MoreParecoxib is a potent and selective COX-2 inhibitor.
MoreEtoricoxib is a specific inhibitor of COX-2.
MoreSulfinpyrazone is one of the most studied platelet COX inhibitors, also a uricosuric agent that competitively inhibits uric acid reabsorption in kidney proximal tubules.
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