RSK


RSK (ribosomal s6 kinase) is a family of protein kinases involved in signal transduction. There are two subfamilies of rsk, p90rsk, also known as MAPK-activated protein kinase-1 (MAPKAP-K1), and p70rsk, also known as S6-H1 Kinase or simply S6 Kinase. There are three variants of p90rsk in humans, rsk 1-3. Rsks are serine/threonine kinases and are activated by the MAPK/ERK pathway. There are two known mammalian homologues of S6 Kinase: S6K1 and S6K2.
  • BI-D1870 EY0449

    BI-D1870是ATP竞争性S6核糖体抑制剂,对RSK1/2/3/4的IC50分别为31 nM/24 nM/18 nM/15 nM,比对MST2,GSK-3β,MARK3,CK1 和Aurora B的抑制性高10到100倍。

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  • PF-4708671 EY0297

    PF-4708671是一种可渗透细胞的p70 S6K1亚型抑制剂,Ki/IC50为20 nM/160 nM,作用于S6K1比作用于S6K2选择性高400倍,作用于S6K1比作用于MSK1和RSK1/2选择性分别高4和20倍以上,是第一个报道的S6K1特异性抑制剂。

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  • AT7867 EY0267

    AT7867是一种有效的,ATP竞争性的Akt1/2/3和p70S6K/PKA抑制剂,IC50分别为32 nM/17 n/47 nM和85 nM/20 nM,对AGC激酶家族以外几乎没有抑制活性。

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  • LY2584702 Tosylate EY1703

    LY-2584702甲苯磺酸盐是p70S6K信号转导口服性抑制剂,能抑制和阻止核糖体S6亚基的磷酸化。

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  • LY2584702 EY1373

    LY-2584702是p70S6K信号转导口服性抑制剂,能抑制和阻止核糖体S6亚基的磷酸化。

    More
  • BI-D1870 EY0449

    BI-D1870是ATP竞争性S6核糖体抑制剂,对RSK1/2/3/4的IC50分别为31 nM/24 nM/18 nM/15 nM,比对MST2,GSK-3β,MARK3,CK1 和Aurora B的抑制性高10到100倍。

    More
  • PF-4708671 EY0297

    PF-4708671是一种可渗透细胞的p70 S6K1亚型抑制剂,Ki/IC50为20 nM/160 nM,作用于S6K1比作用于S6K2选择性高400倍,作用于S6K1比作用于MSK1和RSK1/2选择性分别高4和20倍以上,是第一个报道的S6K1特异性抑制剂。

    More
  • AT7867 EY0267

    AT7867是一种有效的,ATP竞争性的Akt1/2/3和p70S6K/PKA抑制剂,IC50分别为32 nM/17 n/47 nM和85 nM/20 nM,对AGC激酶家族以外几乎没有抑制活性。

    More
  • LY2584702 Tosylate EY1703

    LY-2584702甲苯磺酸盐是p70S6K信号转导口服性抑制剂,能抑制和阻止核糖体S6亚基的磷酸化。

    More
  • LY2584702 EY1373

    LY-2584702是p70S6K信号转导口服性抑制剂,能抑制和阻止核糖体S6亚基的磷酸化。

    More
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