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JAK


Janus kinase (JAK) is a family of intracellular, nonreceptor tyrosine kinases that transduce cytokine-mediated signals via the JAK-STAT pathway. The four JAK family members are:Janus kinase 1 (JAK1),Janus kinase 2 (JAK2),Janus kinase 3 (JAK3) and Tyrosine kinase 2 (TYK2).JAK inhibitors are under development for the treatment of psoriasis, rheumatoid arthritis, polycythemia vera, alopecia, essential thrombocythemia, ulcerative colitis, myeloid metaplasia with myelofibrosis and vitiligo.

  • KT-333 EY8037

    KT-333 是同类首创、强效且选择性的异双功能STAT3降解剂，可募集VHL E3连接酶进行泛素-蛋白酶体介导的降解。它在ALK⁺间变性大细胞淋巴瘤 (ALCL) 的临床前模型中诱导出强大的抗肿瘤活性。

    More

  • Oclacitinib EY2763

    Oclacitinib is a novel inhibitor of JAK family members with IC50 ranging from 10 to 99 nM and JAK1-dependent cytokines with IC50 ranging from 36 to 249 nM, which did not inhibit a panel of 38 non-JAK kinases.

    More

  • Atiprimod dihydrochloride EI0503

    Atiprimod dihydrochloride是JAK2 抑制剂。

    More

  • 1，2，3，4，5，6-Hexabromocyclohexane EI0209

    1，2，3，4，5，6-Hexabromocyclohexane是抑制 JAK2 自磷酸化。

    More

  • ZM 39923 hydrochloride EI3013

    ZM 39923 hydrochloride是活性选择性JAK3抑制剂。

    More

  • KT-333 EY8037

    KT-333 是同类首创、强效且选择性的异双功能STAT3降解剂，可募集VHL E3连接酶进行泛素-蛋白酶体介导的降解。它在ALK⁺间变性大细胞淋巴瘤 (ALCL) 的临床前模型中诱导出强大的抗肿瘤活性。

    More

  • Oclacitinib EY2763

    Oclacitinib is a novel inhibitor of JAK family members with IC50 ranging from 10 to 99 nM and JAK1-dependent cytokines with IC50 ranging from 36 to 249 nM, which did not inhibit a panel of 38 non-JAK kinases.

    More

  • Atiprimod dihydrochloride EI0503

    Atiprimod dihydrochloride是JAK2 抑制剂。

    More

  • 1，2，3，4，5，6-Hexabromocyclohexane EI0209

    1，2，3，4，5，6-Hexabromocyclohexane是抑制 JAK2 自磷酸化。

    More

  • ZM 39923 hydrochloride EI3013

    ZM 39923 hydrochloride是活性选择性JAK3抑制剂。

    More

  • KT-333 EY8037

    KT-333 是同类首创、强效且选择性的异双功能STAT3降解剂，可募集VHL E3连接酶进行泛素-蛋白酶体介导的降解。它在ALK⁺间变性大细胞淋巴瘤 (ALCL) 的临床前模型中诱导出强大的抗肿瘤活性。

    More

  • Oclacitinib EY2763

    Oclacitinib is a novel inhibitor of JAK family members with IC50 ranging from 10 to 99 nM and JAK1-dependent cytokines with IC50 ranging from 36 to 249 nM, which did not inhibit a panel of 38 non-JAK kinases.

    More

  • Atiprimod dihydrochloride EI0503

    Atiprimod dihydrochloride是JAK2 抑制剂。

    More

  • 1，2，3，4，5，6-Hexabromocyclohexane EI0209

    1，2，3，4，5，6-Hexabromocyclohexane是抑制 JAK2 自磷酸化。

    More

  • ZM 39923 hydrochloride EI3013

    ZM 39923 hydrochloride是活性选择性JAK3抑制剂。

    More

  • KT-333 EY8037

    KT-333 是同类首创、强效且选择性的异双功能STAT3降解剂，可募集VHL E3连接酶进行泛素-蛋白酶体介导的降解。它在ALK⁺间变性大细胞淋巴瘤 (ALCL) 的临床前模型中诱导出强大的抗肿瘤活性。

    More

  • Oclacitinib EY2763

    Oclacitinib is a novel inhibitor of JAK family members with IC50 ranging from 10 to 99 nM and JAK1-dependent cytokines with IC50 ranging from 36 to 249 nM, which did not inhibit a panel of 38 non-JAK kinases.

    More

  • Atiprimod dihydrochloride EI0503

    Atiprimod dihydrochloride是JAK2 抑制剂。

    More

  • 1，2，3，4，5，6-Hexabromocyclohexane EI0209

    1，2，3，4，5，6-Hexabromocyclohexane是抑制 JAK2 自磷酸化。

    More

  • ZM 39923 hydrochloride EI3013

    ZM 39923 hydrochloride是活性选择性JAK3抑制剂。

    More
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