Gardos Channel
Gardos Channel (Potassium intermediate/small conductance calcium-activated channel, subfamily N,KCNN4) is a human gene encoding the KCa3.1 protein. The KCa3.1 protein is part of a potentially heterotetrameric voltage-independent potassium channel that is activated by intracellular calcium. Activation is followed by membrane hyperpolarization, which promotes calcium influx. The encoded protein may be part of the predominant calcium-activated potassium channel in T-lymphocytes. This gene is similar to other KCNN family potassium channel genes, but it differs enough to possibly be considered as part of a new subfamily.
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Quisinostat (JNJ-26481585) is a novel second-generation HDACi inhibitor with highest potency for HDAC1 with IC50 of 0.11 nM, modest potent to HDACs 2, 4, 10, and 11; greater than 30-fold selectivity against HDACs 3, 5, 8, and 9 and lowest potency to HDACs 6 and 7. , in NSCLC cells. In vitro, quisinostat has shown anti-proliferative activity against NSCLC cell lines. quisinostat extremely changed protein acetylation patterns of A549 cells and inhibited epithelial-mesenchymal transition (EMT) process.
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Herbimycin A是Src 家族激酶抑制剂。也是Hsp90 抑制剂。
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Gedunin是Hsp90 抑制剂， 展现抗肿瘤抗疟活性。。
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EC 144是高亲和性，活性的选择性 Hsp90 抑制剂。
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CCT 018159是Hsp90 抑制剂。
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