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GPR40(FFAR1)


GPR40,also known as Free fatty acid receptor 1 (FFA1), is a class A G-protein coupled receptor. It is strongly expressed in the cells of the pancreas and to a lesser extent in the brain. This membrane protein binds free fatty acids, acting as a nutrient sensor for regulating energy homeostasis.

  • Decynium 22 EI0945

    Decynium 22是PMAT 抑制剂。

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  • DC 260126 EI0937

    DC 260126是FFA1 (GPR40) 拮抗剂。

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  • AS 2034178 EI0492

    AS 2034178是选择性 FFA1 (GPR40) 激动剂。

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  • TAK-875 EY0273

    TAK-875是一种选择性GPR40激动剂，EC50为14 nM，比油酸有效400倍。

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  • GW9508 EY0587

    GW9508是一种有效的，选择性FFA1(GPR40)激动剂，pEC50为7.32，比作用于GPR120选择性高100倍，以葡萄糖敏感性方式刺激胰岛素的分泌。

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