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LRRK2


LRRK2 (Leucine-rich repeat kinase 2), also known as dardarin, is an enzyme that in humans is encoded by the PARK8 gene. LRRK2 is a member of the leucine-rich repeat kinase family. Variants of this gene are associated with an increased risk of Parkinson's disease and also Crohn's disease.

  • CZC 54252 hydrochloride EI0917

    CZC 54252 hydrochloride是活性的 LRRK2 抑制剂，具有神经保护(neuroprotective)。

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  • PF 06447475 EI2122

    PF 06447475是活性的 LRRK2 抑制剂，具有神经保护活性。

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  • GSK2578215A EY1345

    GSK2578215A是LRRK2高效选择性抑制剂，对野生型LRRK2和突变型G2019S的IC50值约为10nM。

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  • GNE-9605 EY1012

    GNE 9605是一个高效，选择性和能脑渗透的LRRK2抑制剂，IC50为19 nM。

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  • GNE-7915 EY0777

    GNE-7915是高活性，可透过血脑屏障的LRRK2选择性抑制剂，IC50为9 nM，比对其它187种激酶的亲和性高100倍以上。

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