RARs/RXR
RAR (The retinoic acid receptor) is a type of nuclear receptor which can also act as a transcription factor that is activated by both all-trans retinoic acid and 9-cis retinoic acid. There are three retinoic acid receptors (RAR), RAR-alpha, RAR-beta, and RAR-gamma. Each receptor isoform has several splice variants: four- for alpha, four- for beta, and two- for gamma. RXR (The retinoid X receptor) is a type of nuclear receptor that is activated by 9-cis retinoic acid. There are three retinoic X receptors (RXR): RXR-alpha, RXR-beta, and RXR-gamma. RXR heterodimerizes with subfamily 1 nuclear receptors including CAR, FXR, LXR, PPAR, PXR, RAR, TR, and VDR.
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Acitretin, a retinoid that binds to nuclear receptors and regulates gene expression, is a potent activator of the α-secretase ADAM10 gene expression and apoptosis inducer via the CD95 signalling pathway. Acitretin is a systemic retinoid drug used in the treatment of severe psoriasis. Synthetic retinoid that is a metabolite of etretinate. Preferentially binds to cellular retinoic acid binding proteins (CRABPs). Acitretin is a second generation retinoid used for psoriasis.
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HX 531是活性的 RXR 拮抗剂。
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HX 630是RXR synergist。
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Fluorobexarotene是RXR 激动剂。
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Docosahexaenoic acid是RXR 激动剂。
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