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Carbonic Anhydrase

The carbonic anhydrases form a family of enzymes that catalyze the rapid interconversion of carbon dioxide and water to bicarbonate and protons (or vice versa), a reversible reaction that occurs relatively slowly in the absence of a catalyst. The active site of most carbonic anhydrases contains a zinc ion; they are therefore classified as metalloenzymes. One of the functions of the enzyme in animals is to interconvert carbon dioxide and bicarbonate to maintain acid-base balance in blood and other tissues, and to help transport carbon dioxide out of tissues.
  • Dorzolamide HCl EY2778

    Dorzolamide HCl is a water-soluble, potent inhibitor of human carbonic anhydrase II and IV with Ki of 1.9 nM and 31 nM, respectively, used as anti-glaucoma agent.

  • Methazolamide EY2483

    Methazolamide is a carbonic anhydrase inhibitor with Ki of 50 nM, 14 nM and 36 nM for hCA I, hCA II and bCA IV isoforms, respectively.

  • Brinzolamide EY2464

    Brinzolamide is a potent carbonic anhydrase II inhibitor with IC50 of 3.19 nM.

  • Tioxolone EY2418

    Tioxolone is a metalloenzyme carbonic anhydrase I inhibitor with a Ki of 91 nM.

  • Methocarbamol EY2290

    Methocarbamol(Robaxin) is a central muscle relaxant used to treat skeletal muscle spasms.

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