A protease (also called a peptidase or proteinase) is any enzyme that performs proteolysis, that is, begins protein catabolism by hydrolysis of the peptide bonds that link amino acids together in a polypeptide chain. Proteases have evolved multiple times, and different classes of protease can perform the same reaction by completely different catalytic mechanisms. Proteases can be found in animals, plants, fungi, bacteria, archaea and viruses.
These enzymes are involved in a multitude of physiological reactions from simple digestion of food proteins to highly regulated cascades. Proteases can either break specific peptide bonds, depending on the amino acid sequence of a protein, or break down a complete peptide to amino acids . The activity can be a destructive change (abolishing a protein's function or digesting it to its principal components), it can be an activation of a function, or it can be a signal in a signalling pathway.
CRID3 sodium salt是活性的 NLRP3 炎症小体抑制剂(inflammasome ),抑制 IL-1β 的产生。
MoreDimethyl fumarate是Nrf2通路活化剂。
MoreFinasteride是口服活性的睾酮5α-还原酶抑制剂,Ki为10 nM。
MoreCurcumin是具有很好抗氧化活性的天然多酚类化合物,能激活Nrf2起到化疗防护效果。
MoreDexamethasone Sodium Phosphate是一种白介素受体抑制剂,抑制COX-2。
More