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Endothelin Receptor

Endothelin receptors, Including ETA, ETB1, ETB2 and ETC,  are G protein-coupled receptors whose activation result in elevation of intracellular-free calcium.
  • Ambrisentan EY2358

    Ambrisentan, a highly selective antagonist of the endothelin-1 type A receptor with IC50 of 18 nM, is indicated for the treatment of pulmonary arterial hypertension (PAH).

  • FR 139317 EI1144

    FR 139317是高活性选择性 ETA 拮抗剂。

  • CI 1020 EI0786

    CI 1020是高选择性, 口服有效的 ETA 拮抗剂。

  • CGS 35066 EI0770

    CGS 35066是Endothelin-converting enzyme (ECE) 抑制剂。

  • BQ 788 sodium salt EI0614

    BQ 788 sodium salt是选择性 ETB 拮抗剂。

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