STAT


Members of the signal transducer and activator of transcription (STAT) protein family are intracellular transcription factors that mediate many aspects of cellular immunity, proliferation, apoptosis and differentiation. They are primarily activated by membrane receptor-associated Janus kinases (JAK). Dysregulation of this pathway is frequently observed in primary tumors and leads to increased angiogenesis, enhanced survival of tumors and immunosuppression. Gene knockout studies have provided evidence that STAT proteins are involved in the development and function of the immune system and play a role in maintaining immune tolerance and tumor surveillance.
  • Chetomin EI0775

    Chetomin是阻断HIF-1α, HIF-2α 和 STAT2与CBP/p300的相互作用。

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  • SD 1008 EI2517

    SD 1008是JAK2/STAT3 信号通路的抑制剂。

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  • RSVA 405 EI2401

    RSVA 405是AMPK 激动剂, 也是STAT3的抑制剂。

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  • Napabucasin EI1828

    Napabucasin是STAT3 抑制剂,也能阻断肿瘤干细胞的自主更新(self-renewal)。

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  • Stattic EY1827

    Stattic是第一个非肽类小分子,有效抑制STAT3激活和核易位,IC50为5.1 μM,高选择性作用于STAT1。

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  • Chetomin EI0775

    Chetomin是阻断HIF-1α, HIF-2α 和 STAT2与CBP/p300的相互作用。

    More
  • SD 1008 EI2517

    SD 1008是JAK2/STAT3 信号通路的抑制剂。

    More
  • RSVA 405 EI2401

    RSVA 405是AMPK 激动剂, 也是STAT3的抑制剂。

    More
  • Napabucasin EI1828

    Napabucasin是STAT3 抑制剂,也能阻断肿瘤干细胞的自主更新(self-renewal)。

    More
  • Stattic EY1827

    Stattic是第一个非肽类小分子,有效抑制STAT3激活和核易位,IC50为5.1 μM,高选择性作用于STAT1。

    More
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