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Calpains


Calpain is a protein belonging to the family of calcium-dependent, non-lysosomal cysteine proteases (proteolytic enzymes) expressed ubiquitously in mammals and many other organisms. Calpains constitute the C2 family of protease clan CA in the MEROPS database. The calpain proteolytic system includes the calpain proteases, the small regulatory subunit CAPNS1, also known as CAPN4, and the endogenous calpain-specific inhibitor, calpastatin.

  • PD 150606 EI2073

    PD 150606是细胞膜通透性的 calpain 抑制剂。

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  • E-64 EY1852

    E-64 是一种作用于木瓜蛋白酶的选择性的不可逆的半胱氨酸蛋白酶抑制剂，其IC50为9 nM。

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  • MG-132 EY0002

    MG-132是一种蛋白酶体抑制剂，IC50为100 nM。还能抑制钙蛋白酶，IC50为1.2 μM。

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