Ganciclovir (GCV), a hydrophilic, poorly permeable across membranes, synthetic analogue of 20-deoxyguanosine, was developed as an antiviral drug and is currently used to treat cytomegalovirus (CMV) and herpes simplex virus (HSV) infections. Ganciclovir是抗病毒化合物,对1型猫科疱疹病毒的IC50为5.2 μM.
MoreAcyclovir能抑制疱疹病毒的胸苷激酶,IC50为530-750nM。
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