E1 enzymes
E1 enzymes (Ubiquitin-activating enzymes) catalyze the first step in the ubiquitination reaction, which (among other things) can target a protein for degradation via a proteasome. This covalent attachment of ubiquitin or ubiquitin-like proteins to targeted proteins is a major mechanism for regulating protein function in eukaryotic organisms. Many processes such as cell division, immune responses and embryonic development are also regulated by post-transcriptional modification by ubiquitin and ubiquitin-like proteins.
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Gadolinium chloride是Stretch-activated calcium的通道阻断剂， calcium-sensing的受体激动剂。
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Strontium chloride是Calcium sensing receptor (CaSR)的激动剂。
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R 568 hydrochloride是人 calcium-sensing 受体的阳性变构的调节剂（positive allosteric modulator）。
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PYZD 4409是Ubiquitin-activating enzyme (E1) 的抑制剂。
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NSC 624206是Ubiquitin-activating enzyme (E1) 抑制剂。
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