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E1 enzymes

E1 enzymes (Ubiquitin-activating enzymes) catalyze the first step in the ubiquitination reaction, which (among other things) can target a protein for degradation via a proteasome. This covalent attachment of ubiquitin or ubiquitin-like proteins to targeted proteins is a major mechanism for regulating protein function in eukaryotic organisms. Many processes such as cell division, immune responses and embryonic development are also regulated by post-transcriptional modification by ubiquitin and ubiquitin-like proteins.
  • Gadolinium chloride EI1157

    Gadolinium chloride是Stretch-activated calcium的通道阻断剂, calcium-sensing的受体激动剂。

  • Strontium chloride EI2641

    Strontium chloride是Calcium sensing receptor (CaSR)的激动剂。

  • R 568 hydrochloride EI2300

    R 568 hydrochloride是人 calcium-sensing 受体的阳性变构的调节剂(positive allosteric modulator)。

  • PYZD 4409 EI2280

    PYZD 4409是Ubiquitin-activating enzyme (E1) 的抑制剂。

  • NSC 624206 EI1955

    NSC 624206是Ubiquitin-activating enzyme (E1) 抑制剂。

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