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Phosphodiesterase (PDE)

  • Sildenafil EY2818

    Sildenafil is a Phosphodiesterase 5 Inhibitor with IC50 of 5.22 nM.

  • Tadalafil EY2252

    Tadalafil is a potent and selective inhibitor of PDE5A (Phosphodiesterase-5, PDE5) with an IC50 value of 1.8 nM.

  • Pimobendan EY2253

    Pimobendan is a selective inhibitor of phosphodiesterase III(PDE3) with IC50 of 0.32 μM. Pimobendan is an inotropic agent with a dual mechanism of action: it increases myocardial contractility by increasing calcium sensitization to troponin C and it promotes vasodilatio.

  • Ibudilast EI1321

    Ibudilast是PDE 抑制剂 (非选择性)。

  • Gisadenafil besylate EI1187

    Gisadenafil besylate是活性的 PDE5 抑制剂, 口服有效。

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