cAMP
cAMP (Cyclic adenosine monophosphate) is a second messenger important in many biological processes. cAMP is a derivative of adenosine triphosphate (ATP) and used for intracellular signal transduction in many different organisms, conveying the cAMP-dependent pathway. It is also involved in the activation of protein kinases. In addition, cAMP binds to and regulates the function of ion channels such as the HCN channels and a few other cyclic nucleotide-binding proteins such as Epac1 and RAPGEF2.
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Bithionol is a potent inhibitor of soluble adenylyl cyclase(sAC) and has antibacterial and anthelmintic properties along with algaecide activity. Bithionol is a clinically approved anti-parasitic drug; has been shown to inhibit solid tumor growth in several preclinical cancer models.
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Tolbutamide is an inhibitor of cAMP with IC50 of 4 mM.
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Dibutyryl-cAMP， sodium salt是细胞膜通透性 cAMP 类似物。
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cAMPS-Sp， triethylammonium salt是Cell-permeable cAMP类似物。
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cAMPS-Rp， triethylammonium salt是cAMP 拮抗剂。
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