CETP (Cholesteryl ester transfer protein) is a plasma protein that facilitates the transport of cholesteryl esters and triglycerides between the lipoproteins. It collects triglycerides from very-low-density (VLDL) or low-density lipoproteins (LDL) and exchanges them for cholesteryl esters from high-density lipoproteins (HDL), and vice versa. Most of the time, however, CETP does a heteroexchange, trading a triglyceride for a cholesteryl ester or a cholesteryl ester for a triglyceride.
  • Evacetrapib EY1005

    Evacetrapib是高活性CETP选择性抑制剂,IC50为5.5 nM,能在不增加醛固酮和血压的情况下提高高密度脂蛋白胆固醇。

  • Torcetrapib EY0679


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