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MTH1


MLH1(MutL homolog 1) protein is one component of a system of seven DNA mismatch repair (MMR) proteins that work coordinately in sequential steps to initiate repair of DNA mismatches in humans. The seven MMR proteins in humans are MLH1, MLH3, MSH2, MSH3, MSH6, PMS1 and PMS2. In addition, there are Exo1-dependent and Exo1-independent MMR subpathways.

  • SCH 51344 EI2511

    SCH 51344是活性的 MTH1 抑制剂。

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  • Crizotinib EY1172

    Crizotinib (PF-02341066)是一种有效的c-Met抑制剂，作用于人的c-Met激酶时，Ki为4 nM。

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  • TH588 EY0584

    TH588是MTH1(NUDT1)高效选择性抑制剂，IC50值5nM。

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