NMDA
NMDA (N-Methyl-D-aspartic acid or N-Methyl-D-aspartate) is an amino acid derivative that acts as a specific agonist at the NMDA receptor mimicking the action of glutamate, the neurotransmitter which normally acts at that receptor. Unlike glutamate, NMDA only binds to and regulates the NMDA receptor and has no effect on other glutamate receptors. NMDA is an excitotoxin,this trait has applications in behavioral neuroscience research.
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Ambrisentan, a highly selective antagonist of the endothelin-1 type A receptor with IC50 of 18 nM, is indicated for the treatment of pulmonary arterial hypertension (PAH).
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Felbamate (Felbatol,FBM) is an anticonvulsant drug used in the treatment of epilepsy.
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Ibotenic acid是非选择性 NMDA 激动剂。
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Homoquinolinic acid是选择性， 活性的 NMDA 激动剂。
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HU 211是NMDA 受体拮抗剂， 也是NF-κB 抑制剂。
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