Home > 暂无记录 Signal Pathway > Neuronal Signalling

Neuronal Signalling


Neuroscience is the scientific study of the nervous system. Traditionally, neuroscience is recognized as a branch of biology. 

A neuron is an electrically excitable cell that processes and transmits information through electrical and chemical signals. These signals between neurons occur via synapses, specialized connections with other cells. Neurons can connect to each other to form neural networks. Neurons are the core components of the brain and spinal cord of the central nervous system (CNS), and of the ganglia of the peripheral nervous system (PNS).

All neurons are electrically excitable, maintaining voltage gradients across their membranes by means of metabolically driven ion pumps, which combine with ion channels embedded in the membrane to generate intracellular-versus-extracellular concentration differences of ions such as sodium, potassium, chloride, and calcium. Changes in the cross-membrane voltage can alter the function of voltage-dependent ion channels. If the voltage changes by a large enough amount, an all-or-none electrochemical pulse called an action potential is generated, which travels rapidly along the cell's axon, and activates synaptic connections with other cells when it arrives. 

  • PF-3084014 EY5327

    PF-3084014 is a reversible, noncompetitive, and selective γ-secretase inhibitor with IC50 of 6.2 nM.

    More
  • Quisinostat EY2222

    Quisinostat (JNJ-26481585) is a novel second-generation HDACi inhibitor with highest potency for HDAC1 with IC50 of 0.11 nM, modest potent to HDACs 2, 4, 10, and 11; greater than 30-fold selectivity against HDACs 3, 5, 8, and 9 and lowest potency to HDACs 6 and 7. , in NSCLC cells. In vitro, quisinostat has shown anti-proliferative activity against NSCLC cell lines. quisinostat extremely changed protein acetylation patterns of A549 cells and inhibited epithelial-mesenchymal transition (EMT) process.

    More
  • Flurizan EI1133

    Flurizan是γ-secretase 抑制剂, 在体外降低 Aβ42的水平。

    More
  • CPYPP EI0875

    CPYPP是DOCK2-Rac1 interaction inhibitor.。

    More
  • Compound W EI0843

    Compound W是γ-secretase 抑制剂。

    More
  • Current page1, Total Pages15, Total Record72 First Prev 12345 Next Last Goto