Smoothened
Smoothened is a protein that is not a G protein-coupled receptor (it is instead a GPCR-like receptor) that is a component of the hedgehog signaling pathway and is conserved from flies to humans. It is the molecular target of the teratogen cyclopamine. Cellular localization plays an essential role in the function of SMO. Stimulation of the patched receptor by the sonic hedgehog ligand leads to translocation of SMO to the primary cilium. Furthermore, SMO that is mutated in the domain required for ciliary localisation cannot contribute to pathway activation. SMO has also been shown to bind the kinesin motor protein Costal-2 and play a role in the localization of the Ci (Cubitus interruptus transcription factor) complex.
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GSA 10是Smo(Smoothened) 受体激动剂。
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20(S)-Hydroxycholesterol是Hedgehog (Hh) signaling 的变构的激动剂， induces Smo(Smoothened) accumulation。
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SMANT hydrochloride是SMANT hydrochloride可以抑制Smoothened (Smo) accumulation。
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SAG
EI2439
SAG是活性的Smoothened receptor的激动剂，可以激活Hedgehog信号通路。
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PF 5274857 hydrochloride是高亲和性，选择性 Smoothened (Smo) 受体拮抗剂。
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