Bisoprolol fumarate

富马酸比索洛尔,EMD33512,EMD 33512,EMD-33512

Bisoprolol是β1肾上腺素受体阻断剂。

目录号
EY1022
EY1022
EY1022
EY1022
纯度
99.22%
99.22%
99.22%
99.22%
规格
50 mg
100 mg
250 mg
500 mg
原价
310
520
820
1300
售价
310
520
820
1300
库存
现货
现货
现货
现货
订购
订购
订购
订购
订购
订购
  • 生物活性

    Bisoprolol fumarate is a selective type β1 adrenergic receptor blocker.

  • 体外研究

  • 体内研究

  • 激酶实验

  • 细胞实验

  • 动物实验

  • 不同实验动物依据体表面积的等效剂量转换表(数据来源于FDA指南)

    动物 A (mg/kg) = 动物 B (mg/kg)×动物 B的Km系数/动物 AKm系数


    例如,已知某工具药用于小鼠的剂量为88 mg/kg , 则用于大鼠的剂量换算方法:将88 mg/kg 乘以小鼠的Km系数(3),再除以大鼠的Km系数(6),得到该药物用于大鼠的等效剂量44 mg/kg。


  • 参考文献

    [1] Klockow, M., et al. 1986. Arzneimittelforschung. 36: 197-200. PMID: 2870719
    [2] Kaumann, A.J. and Lemoine, H. 1985. Naunyn Schmiedebergs Arch.Pharmacol. 331: 27-39. PMID: 2866449

    分子式
    C22H35NO8
    分子量
    441.52
    CAS号
    104344-23-2
    储存方式
    ﹣20 ℃冷藏长期储存。冰袋运输
    溶剂(常温)
    DMSO
    86 mg/mL
    Water
    85 mg/mL
    Ethanol
    86 mg/mL

    体内溶解度

  • Clinical Trial Information ( data from http://clinicaltrials.gov )

    NCT Number Conditions Interventions Sponsor/Collaborators Phases Start Date Last Updated
    NCT01190436 Hypertension Drug: Bisoprolol Merck KGaA|Merck Inc., Philippines Phase 4 2009-12-01 2017-01-12
    NCT01744873 Fed Drug: Bisoprolol Fumarate Tablet 10 mg|Drug: Bisoprolol IPCA Laboratories Ltd. Phase 1 2012-08-01 2012-12-06
    NCT01741623 Fasting Drug: Bisoprolol Fumarate Tablet 10 mg|Drug: Bisoprolol IPCA Laboratories Ltd. Phase 1 2012-08-01 2012-12-01
    NCT03026088 Heart Failure Drug: Bisoprolol Merck KGaA Phase 4 2017-03-31 2017-03-09
    NCT01977794 Hypertension Drug: Bisoprolol/Amlodipine (Bisoprolol failed group)|Drug: Bisoprolol/Amlodipine (Amlodipine failed group) Merck KGaA Phase 3 2014-03-01 2017-01-12
    NCT01074307 Heart Failure, Congestive Drug: Low Dose Bisoprolol|Drug: High Dose Bisoprolol Merck KGaA|Merck Ltd. Phase 4 2009-10-01 2014-01-13
    NCT00882856 Clozapine-induced Sinustachycardia Drug: Bisoprolol|Drug: Placebo University of Aarhus|Aalborg Universitetshospital|Aalborg University 2009-04-01 2017-01-06
    NCT01251146 Hypertension Drug: Bisoprolol|Drug: Atenolol Merck KGaA|Merck Serono Co., Ltd., China Phase 4 2010-11-01 2017-01-25
    NCT01104558 Chronic Heart Failure Drug: Bisoprolol Merck KGaA|Merck Ltd. Phase 4 2008-12-01 2014-01-20
    NCT02398929 Hypertension Drug: Bisoprolol 2.5 mg|Drug: Placebo Chinese University of Hong Kong Phase 4 2013-01-01 2015-03-20
    NCT01066039 Hypertension|Diabetes Mellitus, Type II Drug: Bisoprolol Merck KGaA|Merck Ltd. Phase 4 2010-04-01 2014-06-04
    NCT01508325 Hypertension Drug: Bisoprolol|Drug: Metoprolol Merck KGaA|Merck Serono Co., Ltd., China Phase 4 2011-12-01 2015-04-28
    NCT01109043 Hypertension Drug: Bisoprolol or bisoprolol + HCTZ Merck KGaA|Merck Gesellschaft mbH, Austria 2009-06-01 2014-07-30
    NCT00702156 Heart Failure|Chronic Obstructive Pulmonary Disease Drug: Bisoprolol|Drug: Placebo NHS Greater Glasgow and Clyde Phase 2 2005-03-01 2008-09-02
    NCT01243827 Hypertension Drug: carvedilol|Drug: bisoprolol Yoshio Matsui|Jichi Medical University Phase 4 2010-11-01 2012-07-18
    NCT02137733 Chronic Heart Failure Drug: Bisoprolol|Drug: Carvedilol Mebix Inc 2013-06-01 2014-05-10
    NCT02832973 Hypertension Resistant to Conventional Therapy Drug: Spironolactone|Drug: Furosemide,|Drug: Amiloride|Drug: Ramipril|Drug: Bisoprolol Sao Jose do Rio Preto University Phase 4 2015-09-01 2016-07-18
    NCT01925300 Healthy Drug: Concor 5mg(Bisoprolol hemifumarate 5mg) 2Tab|Drug: Crestor 20mg(Rosuvastatin calcium 20.80mg) 1Tab|Drug: Concor 5mg 2T and Crestor 20 mg 1Tab CJ HealthCare Corporation Phase 1 2013-07-01 2016-12-28
    NCT01079962 Hypertension Drug: Bisoprolol|Drug: Atenolol Merck KGaA|Merck Ltd. Phase 4 2009-12-01 2014-01-20
    NCT01939509 Hypertension|Metabolic Syndrome Drug: Atenolol|Drug: Bisoprolol Hospital Italiano de Buenos Aires Phase 4 2012-02-01 2014-12-04
    NCT01579058 Aortic Stenosis Drug: bisoprolol|Drug: placebo Asan Medical Center|Merck Sharp & Dohme Corp. Phase 4 2012-07-01 2014-05-08
    NCT01762436 Untreated Essential Hypertension Drug: bisoprolol|Drug: atenolol Ruijin Hospital Phase 4 2010-11-01 2013-01-07

    注:以上所有数据均来自公开文献,并不保证对所有实验均有效,数据仅供参考。

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