Bisoprolol是β1肾上腺素受体阻断剂。
Bisoprolol fumarate is a selective type β1 adrenergic receptor blocker.
动物 A (mg/kg) = 动物 B (mg/kg)×动物 B的Km系数/动物 A的Km系数 | |
例如,已知某工具药用于小鼠的剂量为88 mg/kg , 则用于大鼠的剂量换算方法:将88 mg/kg 乘以小鼠的Km系数(3),再除以大鼠的Km系数(6),得到该药物用于大鼠的等效剂量44 mg/kg。
[1] Klockow, M., et al. 1986. Arzneimittelforschung. 36: 197-200. PMID: 2870719
[2] Kaumann, A.J. and Lemoine, H. 1985. Naunyn Schmiedebergs Arch.Pharmacol. 331: 27-39. PMID: 2866449
分子式 C22H35NO8 |
分子量 441.52 |
CAS号 104344-23-2 |
储存方式 ﹣20 ℃冷藏长期储存。冰袋运输 |
溶剂(常温) |
DMSO 86 mg/mL |
Water 85 mg/mL |
Ethanol 86 mg/mL |
体内溶解度
NCT Number | Conditions | Interventions | Sponsor/Collaborators | Phases | Start Date | Last Updated |
NCT01190436 | Hypertension | Drug: Bisoprolol | Merck KGaA|Merck Inc., Philippines | Phase 4 | 2009-12-01 | 2017-01-12 |
NCT01744873 | Fed | Drug: Bisoprolol Fumarate Tablet 10 mg|Drug: Bisoprolol | IPCA Laboratories Ltd. | Phase 1 | 2012-08-01 | 2012-12-06 |
NCT01741623 | Fasting | Drug: Bisoprolol Fumarate Tablet 10 mg|Drug: Bisoprolol | IPCA Laboratories Ltd. | Phase 1 | 2012-08-01 | 2012-12-01 |
NCT03026088 | Heart Failure | Drug: Bisoprolol | Merck KGaA | Phase 4 | 2017-03-31 | 2017-03-09 |
NCT01977794 | Hypertension | Drug: Bisoprolol/Amlodipine (Bisoprolol failed group)|Drug: Bisoprolol/Amlodipine (Amlodipine failed group) | Merck KGaA | Phase 3 | 2014-03-01 | 2017-01-12 |
NCT01074307 | Heart Failure, Congestive | Drug: Low Dose Bisoprolol|Drug: High Dose Bisoprolol | Merck KGaA|Merck Ltd. | Phase 4 | 2009-10-01 | 2014-01-13 |
NCT00882856 | Clozapine-induced Sinustachycardia | Drug: Bisoprolol|Drug: Placebo | University of Aarhus|Aalborg Universitetshospital|Aalborg University | 2009-04-01 | 2017-01-06 | |
NCT01251146 | Hypertension | Drug: Bisoprolol|Drug: Atenolol | Merck KGaA|Merck Serono Co., Ltd., China | Phase 4 | 2010-11-01 | 2017-01-25 |
NCT01104558 | Chronic Heart Failure | Drug: Bisoprolol | Merck KGaA|Merck Ltd. | Phase 4 | 2008-12-01 | 2014-01-20 |
NCT02398929 | Hypertension | Drug: Bisoprolol 2.5 mg|Drug: Placebo | Chinese University of Hong Kong | Phase 4 | 2013-01-01 | 2015-03-20 |
NCT01066039 | Hypertension|Diabetes Mellitus, Type II | Drug: Bisoprolol | Merck KGaA|Merck Ltd. | Phase 4 | 2010-04-01 | 2014-06-04 |
NCT01508325 | Hypertension | Drug: Bisoprolol|Drug: Metoprolol | Merck KGaA|Merck Serono Co., Ltd., China | Phase 4 | 2011-12-01 | 2015-04-28 |
NCT01109043 | Hypertension | Drug: Bisoprolol or bisoprolol + HCTZ | Merck KGaA|Merck Gesellschaft mbH, Austria | 2009-06-01 | 2014-07-30 | |
NCT00702156 | Heart Failure|Chronic Obstructive Pulmonary Disease | Drug: Bisoprolol|Drug: Placebo | NHS Greater Glasgow and Clyde | Phase 2 | 2005-03-01 | 2008-09-02 |
NCT01243827 | Hypertension | Drug: carvedilol|Drug: bisoprolol | Yoshio Matsui|Jichi Medical University | Phase 4 | 2010-11-01 | 2012-07-18 |
NCT02137733 | Chronic Heart Failure | Drug: Bisoprolol|Drug: Carvedilol | Mebix Inc | 2013-06-01 | 2014-05-10 | |
NCT02832973 | Hypertension Resistant to Conventional Therapy | Drug: Spironolactone|Drug: Furosemide,|Drug: Amiloride|Drug: Ramipril|Drug: Bisoprolol | Sao Jose do Rio Preto University | Phase 4 | 2015-09-01 | 2016-07-18 |
NCT01925300 | Healthy | Drug: Concor 5mg(Bisoprolol hemifumarate 5mg) 2Tab|Drug: Crestor 20mg(Rosuvastatin calcium 20.80mg) 1Tab|Drug: Concor 5mg 2T and Crestor 20 mg 1Tab | CJ HealthCare Corporation | Phase 1 | 2013-07-01 | 2016-12-28 |
NCT01079962 | Hypertension | Drug: Bisoprolol|Drug: Atenolol | Merck KGaA|Merck Ltd. | Phase 4 | 2009-12-01 | 2014-01-20 |
NCT01939509 | Hypertension|Metabolic Syndrome | Drug: Atenolol|Drug: Bisoprolol | Hospital Italiano de Buenos Aires | Phase 4 | 2012-02-01 | 2014-12-04 |
NCT01579058 | Aortic Stenosis | Drug: bisoprolol|Drug: placebo | Asan Medical Center|Merck Sharp & Dohme Corp. | Phase 4 | 2012-07-01 | 2014-05-08 |
NCT01762436 | Untreated Essential Hypertension | Drug: bisoprolol|Drug: atenolol | Ruijin Hospital | Phase 4 | 2010-11-01 | 2013-01-07 |
注:以上所有数据均来自公开文献,并不保证对所有实验均有效,数据仅供参考。
相关化合物库
使用AMQUAR产品发表文献后请联系我们