PPAR


PPARs (peroxisome proliferator-activated receptors) are a group of nuclear receptor proteins that function as transcription factors regulating the expression of genes. PPARs play essential roles in the regulation of cellular differentiation, development, and metabolism (carbohydrate, lipid, protein), and tumorigenesis of higher organisms.
  • MK-886 EY5645

    MK-886 is an inhibitor of leukotriene biosynthesis, inhibiting 5-lipoxygenase-activating protein (FLAP). It is also a moderately potent PPARα antagonist.

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  • NXT629 EY5417

    Nxt629 is an effective, selective and competitive PPAR- α Antagonists, human PPAR α The IC50 value of is 77 nm, which is more selective than other nuclear hormone receptors, such as ppar δ, PPAR γ, Er β, GR and tr β, IC50 values are 6.0, 15, 15.2, 32.5 and >100 respectively μ M。

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  • Fenofibric acid EY2647

    Fenofibric acid is a fibrate that acts as a lipid-lowering agent, decreasing low-density lipoprotein cholesterol and triglycerides.

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  • Bezafibrate EY2534

    Bezafibrate is the first clinically tested dual and pan-PPAR co-agonism.

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  • Ciprofibrate EY2423

    Ciprofibrate is a peroxisome proliferator-activated receptor agonist.

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  • MK-886 EY5645

    MK-886 is an inhibitor of leukotriene biosynthesis, inhibiting 5-lipoxygenase-activating protein (FLAP). It is also a moderately potent PPARα antagonist.

    More
  • NXT629 EY5417

    Nxt629 is an effective, selective and competitive PPAR- α Antagonists, human PPAR α The IC50 value of is 77 nm, which is more selective than other nuclear hormone receptors, such as ppar δ, PPAR γ, Er β, GR and tr β, IC50 values are 6.0, 15, 15.2, 32.5 and >100 respectively μ M。

    More
  • Fenofibric acid EY2647

    Fenofibric acid is a fibrate that acts as a lipid-lowering agent, decreasing low-density lipoprotein cholesterol and triglycerides.

    More
  • Bezafibrate EY2534

    Bezafibrate is the first clinically tested dual and pan-PPAR co-agonism.

    More
  • Ciprofibrate EY2423

    Ciprofibrate is a peroxisome proliferator-activated receptor agonist.

    More
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