Potassium Channel

potassium channels are the most widely distributed type of ion channel and are found in virtually all living organisms. They form potassium-selective pores that span cell membranes. Furthermore potassium channels are found in most cell types and control a wide variety of cell functions. These channels act to set or reset the resting potential in many cells. In excitable cells, such as neurons, the delayed counterflow of potassium ions shapes the action potential.
  • Sildenafil EY2818

    Sildenafil is a Phosphodiesterase 5 Inhibitor with IC50 of 5.22 nM.

  • Hydralazine HCl EY2789

    Hydralazine Hydrochloride is a direct-acting vasodilator that is used as an antihypertensive agent.

  • Hexachlorophene EY2715

    Hexachlorophene is a potent KCNQ1/KCNE1 potassium channel activator with EC50 of 4.61 ± 1.29 μM; also is an inhibitor of Wnt/beta-catenin signaling.

  • Gliclazide EY2416

    Gliclazide (Diamicron) is a whole-cell beta-cell ATP-sensitive potassium currents blocker with an IC50 of 184 ± 30 nM.

  • Sotalol EY2389

    Sotalol (Betapace) is a non-selective beta blocker and a potassium channel blocker with an IC50 of 43 μM

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