PARs
Protease-activated receptors are a subfamily of related G protein-coupled receptors that are activated by cleavage of part of their extracellular domain. They are highly expressed in platelets, but also on endothelial cells, myocytes and neurons.Most of the PAR family act through the actions of G-proteins i (cAMP inhibitory), 12/13 (Rho and Ras activation) and q (calcium signalling) to cause cellular actions.
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Vorapaxar is a thrombin receptor (protease-activated receptor, PAR-1) antagonist.
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FR 171113是PAR1 拮抗剂。
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AC 264613是PAR2 受体 激动剂。
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SCH 79797 dihydrochloride是活性的， 选择性非肽类PAR1 拮抗剂。
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RWJ 56110是选择性 PAR1 拮抗剂。
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Vorapaxar is a thrombin receptor (protease-activated receptor, PAR-1) antagonist.
More
-
FR 171113是PAR1 拮抗剂。
More
-
AC 264613是PAR2 受体 激动剂。
More
-
SCH 79797 dihydrochloride是活性的， 选择性非肽类PAR1 拮抗剂。
More
-
RWJ 56110是选择性 PAR1 拮抗剂。
More
