CDK


CDK (Cyclin-dependent kinases) is a group of serine/threonine kinases. It is activated by binding to cyclin and participates in the regulation of cell cycle.
Most of the known cyclin-CDK complexes regulate the progression through the cell cycle. Animal cells contain at least nine CDKs, four of which, CDK1, 2, 3, and 4, are directly involved in cell cycle regulation. In mammalian cells, CDK1, with its partners cyclin A2 and B1, alone can drive the cell cycle. Another one, CDK7, is involved indirectly as the CDK-activating kinase. A cyclin-dependent kinase inhibitor (CKI) is a protein that interacts with a cyclin-CDK complex to block kinase activity, usually during G1 or in response to signals from the environment or from damaged DNA. 
  • CGP 60474 EI0758

    CGP 60474是活性的双效cdk1/cdk2 抑制剂。

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  • Arcyriaflavin A EI0478

    Arcyriaflavin A是活性的cdk4/cyclin D1,CaM 激酶 II 抑制剂。(anti-HCMV)。

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  • Aminopurvalanol A EI0436

    Aminopurvalanol A是Cyclin-dependent 激酶抑制剂。

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  • (R)-DRF053 dihydrochloride EI0127

    (R)-DRF053 dihydrochloride是Dual CK1/cdk 抑制剂。

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  • SR 1664 EI2614

    SR 1664是高亲和性 PPARγ 配体, 阻断 Cdk5-dependent PPARγ phosphorylation。

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