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Integrase


Integration occurs following production of the double-stranded viral DNA by the viral RNA/DNA-dependent DNA polymerase reverse transcriptase. The main function of IN is to insert the viral DNA into the host chromosomal DNA, a step that is essential for HIV replication. Integration is a point of no return for the cell, which becomes a permanent carrier of the viral genome (provirus). Integration is in part responsible for the persistence of retroviral infections.

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    Elvitegravir (EVG, JTK-303/GS-9137)是HIV整合酶抑制剂,对HIV-1 IIIB,HIV-2 EHO和HIV-2 ROD的IC50分别为0.7 nM,2.8 nM和1.4 nM。

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  • Dolutegravir EY1145

    Dolutegravir 是整合酶抑制剂,IC50为2.7 nM,对raltegravir-抗性的突变型Y143R,Q148K,N155H和G140S/Q148H有一定抑制性。

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  • Raltegravir EY0271

    Raltegravir是一种有效的整合酶链转移抑制剂,作用于WT和S217Q原型泡沫病毒(PFV)整合酶,IC50分别为90 nM和40 nM。

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  • Elvitegravir EY1540

    Elvitegravir (EVG, JTK-303/GS-9137)是HIV整合酶抑制剂,对HIV-1 IIIB,HIV-2 EHO和HIV-2 ROD的IC50分别为0.7 nM,2.8 nM和1.4 nM。

    More
  • Dolutegravir EY1145

    Dolutegravir 是整合酶抑制剂,IC50为2.7 nM,对raltegravir-抗性的突变型Y143R,Q148K,N155H和G140S/Q148H有一定抑制性。

    More
  • Raltegravir EY0271

    Raltegravir是一种有效的整合酶链转移抑制剂,作用于WT和S217Q原型泡沫病毒(PFV)整合酶,IC50分别为90 nM和40 nM。

    More
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