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Angiotensin Receptor


The angiotensin receptors are a class of G protein-coupled receptors with angiotensin II as their ligands. They are important in the renin-angiotensin system: they are responsible for the signal transduction of the vasoconstricting stimulus of the main effector hormone, angiotensin II. The AT1 and AT2 receptors share a sequence identity of ~30%, but have a similar affinity for angiotensin II, which is their main ligand. Other poorly characterized subtypes include the AT3 and AT4 receptors. The AT4 receptor is activated by the angiotensin II metabolite angiotensin IV, and may play a role in regulation of the CNS extracellular matrix, as well as modulation of oxytocin release.

  • Angiotensin II EY2824

    Angiotensin II human is a peptide hormone that causes vasoconstriction and a subsequent increase in blood pressure.

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  • PD123319 EY0811

    PD 123319是血管紧张素II受体拮抗剂，IC50为34 nM。

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