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GABA Receptor


GABA receptors are a class of receptors that respond to the neurotransmitter gamma-aminobutyric acid (GABA), the chief inhibitory compound in the mature vertebrate central nervous system. GABA receptors influence cognition by coordinating with glutamatergic processes. There are two classes of GABA receptors: GABAA and GABAB. GABAA receptors are ligand-gated ion channels; whereas GABAB receptors are G protein-coupled receptors, also called metabotropic receptors. A subclass of ionotropic GABA receptors, insensitive to typical allosteric modulators of GABAA receptor channels such as benzodiazepines and barbiturates, designated GABAС receptor.

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