GPR120(FFA4)
GPR120 is a member of the rhodopsin family of G protein-coupled receptors (GPRs). GPR120 has also been shown to mediate the anti-inflammatory and insulin-sensitizing effects of omega 3 fatty acids. Lack of GPR120 is responsible for reduced fat metabolism, thereby leading to obesity. Additionally, GPR120 has been implicated to be involved in the ability to taste fats. It is expressed in taste bud cells (specifically cell type II, which contain other G-protein coupled taste receptors), and its absence leads to reduced preference to two types of fatty acid (linoleic acid and oleic acid), as well as decreased neuronal response to oral fatty acids.
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Grifolic acid是选择性 部分 FFA4 (GPR120) 激动剂。
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GSK 137647是活性选择性 FFA4 (GPR120) 激动剂。
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AH 7614是选择性 FFA4 (GPR120) 拮抗剂。
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TUG 891是活性的，选择性 FFA4 (GPR120) 激动剂。
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GW9508是一种有效的，选择性FFA1(GPR40)激动剂，pEC50为7.32，比作用于GPR120选择性高100倍，以葡萄糖敏感性方式刺激胰岛素的分泌。
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