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GPR120 is a member of the rhodopsin family of G protein-coupled receptors (GPRs). GPR120 has also been shown to mediate the anti-inflammatory and insulin-sensitizing effects of omega 3 fatty acids. Lack of GPR120 is responsible for reduced fat metabolism, thereby leading to obesity. Additionally, GPR120 has been implicated to be involved in the ability to taste fats. It is expressed in taste bud cells (specifically cell type II, which contain other G-protein coupled taste receptors), and its absence leads to reduced preference to two types of fatty acid (linoleic acid and oleic acid), as well as decreased neuronal response to oral fatty acids.
  • Grifolic acid EI1231

    Grifolic acid是选择性 部分 FFA4 (GPR120) 激动剂。

  • GSK 137647 EI1238

    GSK 137647是活性选择性 FFA4 (GPR120) 激动剂。

  • AH 7614 EI0406

    AH 7614是选择性 FFA4 (GPR120) 拮抗剂。

  • TUG 891 EI2823

    TUG 891是活性的,选择性 FFA4 (GPR120) 激动剂。

  • GW9508 EY0587


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