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Gamma-secretase


Gamma secretase (γ-secretase) is a multi-subunit protease complex, itself an integral membrane protein, that cleaves single-pass transmembrane proteins at residues within the transmembrane domain. Proteases of this type are known as intramembrane proteases. Gamma secretase is also critical in the related processing of several other type I integral membrane proteins, such as Notch,ErbB4,E-cadherin, N-cadherin,ephrin-B2,or CD44. The gamma secretase complex consists of four individual proteins: PSEN1 (presenilin-1),nicastrin, APH-1 (anterior pharynx-defective 1), and PEN-2 (presenilin enhancer 2).
  • Flurizan EI1133

    Flurizan是γ-secretase 抑制剂, 在体外降低 Aβ42的水平。

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  • Compound W EI0843

    Compound W是γ-secretase 抑制剂。

    More
  • Begacestat EI0551

    Begacestat是γ-secretase 抑制剂, lowers Aβ40,Aβ42 levels。

    More
  • TC-E 5006 EI2701

    TC-E 5006是γ-secretase调节剂,降低Aβ42的水平。

    More
  • MRK 560 EI1766

    MRK 560是γ分泌酶(secretase) 抑制剂可以抑制淀粉样斑块沉积(amyloid plaque deposits)。

    More
  • Flurizan EI1133

    Flurizan是γ-secretase 抑制剂, 在体外降低 Aβ42的水平。

    More
  • Compound W EI0843

    Compound W是γ-secretase 抑制剂。

    More
  • Begacestat EI0551

    Begacestat是γ-secretase 抑制剂, lowers Aβ40,Aβ42 levels。

    More
  • TC-E 5006 EI2701

    TC-E 5006是γ-secretase调节剂,降低Aβ42的水平。

    More
  • MRK 560 EI1766

    MRK 560是γ分泌酶(secretase) 抑制剂可以抑制淀粉样斑块沉积(amyloid plaque deposits)。

    More
  • Flurizan EI1133

    Flurizan是γ-secretase 抑制剂, 在体外降低 Aβ42的水平。

    More
  • Compound W EI0843

    Compound W是γ-secretase 抑制剂。

    More
  • Begacestat EI0551

    Begacestat是γ-secretase 抑制剂, lowers Aβ40,Aβ42 levels。

    More
  • TC-E 5006 EI2701

    TC-E 5006是γ-secretase调节剂,降低Aβ42的水平。

    More
  • MRK 560 EI1766

    MRK 560是γ分泌酶(secretase) 抑制剂可以抑制淀粉样斑块沉积(amyloid plaque deposits)。

    More
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