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Dopamine β-hydroxylase


Dopamine beta-hydroxylase (DBH) is an enzyme that in humans is encoded by the DBH gene.t is the only enzyme involved in the synthesis of small-molecule neurotransmitters that is membrane-bound, making norepinephrine the only known transmitter synthesized inside vesicles. It is expressed in noradrenergic nerve terminals of the central and peripheral nervous systems, as well as in chromaffin cells of the adrenal medulla. DBH is inhibited by disulfiram tropolone, and most selectively by nepicastat.

  • Nepicastat hydrochloride EI1853

    Nepicastat hydrochloride是活性的，选择性 dopamine β-hydroxylase (DBH) 抑制剂， 口服有效。

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  • Disulfiram EY0332

    Disulfiram是氨基甲酸酯衍生物，可作用于多巴胺-β-羟化酶。

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