DPP4 (Dipeptidyl peptidase-4) is an antigenic enzyme expressed on the surface of most cell types and is associated with immune regulation, signal transduction and apoptosis. It is a rather indiscriminate enzyme for which a diverse range of substrates are known. The substrates of CD26/DPPIV are proline(or alanine)-containing peptides and include growth factors, chemokines, neuropeptides, and vasoactive peptides. DPP4 plays a major role in glucose metabolism. It is responsible for the degradation of incretins such as GLP-1. Furthermore, it appears to work as a suppressor in the development of cancer and tumours.
  • Teneligliptin hydrobromide EY2719

    Teneligliptin is a novel, potent, and long-lasting dipeptidyl peptidase-4 inhibitor; competitively inhibited human plasma, rat plasma, and human recombinant DPP-4 in vitro, with IC50 values of approximately 1 nM.

  • Alogliptin EY2426

    Alogliptin is a potent, selective inhibitor of DPP-4 with IC50 of <10 nM, exhibits greater than 10,000-fold selectivity over DPP-8 and DPP-9. Phase 4.

  • DPPI 1c hydrochloride EI1035

    DPPI 1c hydrochloride是Dipeptidyl peptidase IV (DPP-IV) 抑制剂。

  • PK 44 phosphate EI2183

    PK 44 phosphate是活性的,选择性 dipeptidyl peptidase IV (DPP-IV) 抑制剂。

  • NVP DPP 728 dihydrochloride EI1974

    NVP DPP 728 dihydrochloride是活性的,口服有效 dipeptidyl peptidase IV (DPP-IV) 抑制剂。

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