HIV (The human immunodeficiency virus) is a lentivirus (a subgroup of retrovirus) that causes HIV infection and over time acquired immunodeficiency syndrome (AIDS). HIV infects vital cells in the human immune system such as helper T cells (specifically CD4+ T cells), macrophages, and dendritic cells.[4] HIV infection leads to low levels of CD4+ T cells through a number of mechanisms, including pyroptosis of abortively infected T cells, apoptosis of uninfected bystander cells,[6] direct viral killing of infected cells, and killing of infected CD4+ T cells by CD8 cytotoxic lymphocytes that recognize infected cells.[7] When CD4+ T cell numbers decline below a critical level, cell-mediated immunity is lost, and the body becomes progressively more susceptible to opportunistic infections.
  • Atazanavir EY2738

    Atazanavir is an azapeptide and HIV-protease inhibitor that is used in the treatment of HIV infections and AIDS in combination with other anti-HIV agents.

  • Saquinavir mesylate EI2446

    Saquinavir mesylate是HIV 蛋白酶抑制剂。

  • NBD 556 EI1834

    NBD 556是CD4 mimetic,NBD 556可以阻断 HIV-1 进入细胞。。

  • BMS-626529 EY2840

    BMS-626529是HIV-1 gp120抑制剂,能阻止其与CD4+ T细胞的结合。

  • Maraviroc EY1740

    Maraviroc是一种趋化因子受体CCR5抑制剂,作用于MIP-1α, MIP-1β和RANTES 时,IC50分别为3.3 nM, 7.2 nM和5.2 nM。

  • Current page1, Total Pages3, Total Record14 First Prev 123 Next Last Goto