Home > Signal Pathway > Apoptosis > Bcl-2 Family

Bcl-2 Family

The Bcl-2 Family  consists of apoptosis regulator Bcl-2 and its homologues. These proteins govern mitochondrial outer membrane permeabilization (MOMP) and can be either pro-apoptotic (Bax, BAD, Bak and Bok among others) or anti-apoptotic (including Bcl-2 proper, Bcl-xL, and Bcl-w, among an assortment of others). Bcl-x(L), Bcl-x(S) and Bcl-xβ are three isoforms derived by alternative RNA splicing.
  • Masitinib EY2221

    Masitinib, a novel phenylaminothiazole-type derivative, is an inhibitor of the class III receptor tyrosine kinase stem-cell growth factor receptor (c-Kit) with IC50 of 200 nM, platelet-derived growth factor receptor α and β and the non-receptor tyrosine kinase Lyn(PDGFRα/β with IC50 of 540 nM/800 nM).

  • Muristerone A EI1795

    Muristerone A是Muristerone A has antiapoptotic activity and stimulates Bcl-XL mRNA transcription。

  • ABT-263 EY1403

    ABT-263 (Navitoclax)是一种有效的Bcl-xL, Bcl-2和Bcl-w抑制剂,Ki分别为≤0.5 nM,≤1 nM和≤1 nM,但与Mcl-1和A1结合微弱。

  • Obatoclax Mesylate EY1271

    Obatoclax (GX15-070)是Bcl-2 homology domain-3 (BH3)的类似物,对各种抗凋亡的Bcl-2家族蛋白的IC50平均为3 uM,如对Mcl-1(IC50为2.9 uM)和Bfl-1(IC50为5 uM)。

  • ABT-737 EY1090

    ABT-737是一种类BH3抑制剂,能同时抑制Bcl-xL, Bcl-2和Bcl-w ,EC50分别为78.7 nM,30.3 nM和197.8 nM;但对Mcl-1, Bcl-B及Bfl-1没有抑制作用。

  • Current page1, Total Pages1, Total Record5 First Prev 1 Next Last Goto