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Somatostatin Receptor


Somatostatin (GHIH)  is a peptide hormone that regulates the endocrine system and affects neurotransmission and cell proliferation via interaction with G protein-coupled somatostatin receptors and inhibition of the release of numerous secondary hormones. Somatostatin inhibits insulin and glucagon secretion. There are five known somatostatin receptors: SST1(SSTR1),SST2 (SSTR2),SST3 (SSTR3),SST4 (SSTR4) and SST5 (SSTR5). All are G protein-coupled seven transmembrane receptors.

  • (1R，1'S，3'R/1R，1'R，3'S)-L-054，264 EI0104

    (1R，1'S，3'R/1R，1'R，3'S)-L-054，264是活性的，选择性 sst2 激动剂。

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  • NNC 26-9100 EI1902

    NNC 26-9100是选择性 sst4 激动剂。

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  • L-803，087 trifluoroacetate EI1498

    L-803，087 trifluoroacetate是活性的，选择性 sst4 激动剂。

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  • L-817，818 EI1500

    L-817，818是活性的，选择性 sst5 激动剂。

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