URAT1
URAT1 (member 12,SLC22A12)s a protein from solute carrier family 22 (organic anion/cation transporter). The protein is a urate transporter and urate-anion exchanger which regulates the level of urate in the blood. This protein is an integral membrane protein primarily found in kidney.
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Tucatinib (Irbinitinib, ONT-380, ARRY-380) 是一种具有口服活性、可逆的、ATP竞争性的的ErbB2（HER2）小分子抑制剂。在细胞实验中，ARRY-380对ErbB-2和p95 HER2的IC50s分别为8 nM和7 nM，对HER2的选择性是对EGFR的500倍。具有潜在的抗肿瘤活性。
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Pralidoxime is an antidote to organophosphate pesticides and chemicals.
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Itopride hydrochloride is an AChE inhibitor (acetylcholinesterase) and D2DR inhibitor. Itopride is used as a gastroprokinetic agent. The IC50 of itopride with AChE is 2.04 +/- 0.27 μM.
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Cl-4AS-1是Steroidal androgen 受体激动剂。
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ASP8273 is a small molecule, irreversible TKI inhibitor that inhibits the kinase activity of EGFR mutations including T790M, with limited activity against EGFR wild-type NSCLC. In the in vitro enzymatic and cell-based assays, ASP8273 were evaluated against EGFR mutantsand WT EGFR.
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