Aromatase
Aromatase (estrogen synthetase or estrogen synthase) is an enzyme responsible for a key step in the biosynthesis of estrogens. In particular, aromatase is responsible for the aromatization of androgens into estrogens. The aromatase enzyme can be found in many tissues including gonads, brain, adipose tissue, placenta, blood vessels, skin, and bone, as well as in tissue of endometriosis, uterine fibroids, breast cancer, and endometrial cancer. The inhibition of aromatase can cause hypoestrogenism (low estrogen levels). Many natural elements have been found to have inhibiting effects on aromatase.
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Bifonazole is an antifungal agent and a prostatic aromatase activity inhibitor with IC50 of 1.6 μM.
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Aminoglutethimide is an aromatase inhibitor with IC50 of 10 μM.
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Letrozole (INN, trade name Femara) is an oral non-steroidal aromatase inhibitor for the treatment of hormonally-responsive breast cancer after surgery.
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Formestane是I型芳香酶抑制剂。
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Anastrozole(ZD1033) 是选择性CYP19抑制剂，IC50为15 nM，对肾上腺皮质素合成无影响。
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