5-alpha Reductase
5-alpha Reductase are enzymes involved in steroid metabolism. They participate in 3 metabolic pathways: bile acid biosynthesis, androgen and estrogen metabolism. There are three isoenzymes of 5α-reductase, which vary in different tissues with age.The mechanism of 5α reductase inhibition is complex, but involves the binding of NADPH to the enzyme followed by the substrate. 5α-reductase inhibitor drugs are used in benign prostatic hyperplasia, prostate cancer, pattern hair loss (androgenetic alopecia), and hormone replacement therapy for transgender women.
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Finasteride是口服活性的睾酮5α-还原酶抑制剂，Ki为10 nM。
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Dutasteride是5α还原酶同工酶抑制剂，还可能因其结构域DHT相似对雄激素受体（AR）产生脱靶效应。
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Finasteride是口服活性的睾酮5α-还原酶抑制剂，Ki为10 nM。
More
-
Dutasteride是5α还原酶同工酶抑制剂，还可能因其结构域DHT相似对雄激素受体（AR）产生脱靶效应。
More
