Home > Signal Pathway > Metabolism > 5-alpha Reductase

5-alpha Reductase


5-alpha Reductase are enzymes involved in steroid metabolism. They participate in 3 metabolic pathways: bile acid biosynthesis, androgen and estrogen metabolism. There are three isoenzymes of 5α-reductase, which vary in different tissues with age.The mechanism of 5α reductase inhibition is complex, but involves the binding of NADPH to the enzyme followed by the substrate. 5α-reductase inhibitor drugs are used in benign prostatic hyperplasia, prostate cancer, pattern hair loss (androgenetic alopecia), and hormone replacement therapy for transgender women.
  • Finasteride EY0545

    Finasteride是口服活性的睾酮5α-还原酶抑制剂,Ki为10 nM。

    More
  • Dutasteride EY1006

    Dutasteride是5α还原酶同工酶抑制剂,还可能因其结构域DHT相似对雄激素受体(AR)产生脱靶效应。

    More
  • Finasteride EY0545

    Finasteride是口服活性的睾酮5α-还原酶抑制剂,Ki为10 nM。

    More
  • Dutasteride EY1006

    Dutasteride是5α还原酶同工酶抑制剂,还可能因其结构域DHT相似对雄激素受体(AR)产生脱靶效应。

    More
  • Current page1, Total Pages1, Total Record2 First Prev 1 Next Last Goto