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5-Lipoxygenase is a non-heme iron-containing enzyme that in humans is encoded by the ALOX5 gene. 5-lipoxygenase is a member of the lipoxygenase family of enzymes. It transforms EFA substrates into leukotrienes as well as a wide range of other biologically active products. ALOX5 is a current target for pharmaceutical intervention in a number of diseases.
  • Malotilate EY2223

    Malotilate is a new drug suggested for use in chronic liver diseases. It is shown here to prevent liver damage caused by CCl4. It has been shown to inhibit 5-1ipoxygenase in human macrophages selectively.

  • U73122 EY0607


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