Akt
Akt (Protein kinase B (PKB)) is a serine/threonine-specific protein kinase that plays a key role in multiple cellular processes such as glucose metabolism, apoptosis, cell proliferation, transcription and cell migration.
Akt regulates cellular survival and metabolism by binding and regulating many downstream effectors, e.g. Nuclear Factor-κB, Bcl-2 family proteins and MDM2.
Akt could promote growth factor-mediated cell survival both directly and indirectly. BAD is a pro-apoptotic protein of the Bcl-2 family. Akt could phosphorylate BAD on Ser136, which makes BAD dissociate from the Bcl-2/Bcl-X complex and lose the pro-apoptotic function. Akt could also activate NF-κB via regulating IκB kinase (IKK), thus result in transcription of pro-survival genes.
Akt1 has also been implicated in angiogenesis and tumor development.
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FPA 124是Akt/PKB 抑制剂。
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10-DEBC hydrochloride是选择性 Akt/PKB 抑制剂。
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PIT 1是抑制 Akt 信号通路。
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A-674563是Akt1抑制剂，IC50为14 nM，还能抑制PKA和CDK2，IC50分别为16和46 nM。
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Perifosine (KRX-0401)是一种新型的Akt抑制剂，IC50为4.7 μM，靶向作用于Akt的pleckstrin homology (PH)区。
More
-
FPA 124是Akt/PKB 抑制剂。
More
-
10-DEBC hydrochloride是选择性 Akt/PKB 抑制剂。
More
-
PIT 1是抑制 Akt 信号通路。
More
-
A-674563是Akt1抑制剂，IC50为14 nM，还能抑制PKA和CDK2，IC50分别为16和46 nM。
More
-
Perifosine (KRX-0401)是一种新型的Akt抑制剂，IC50为4.7 μM，靶向作用于Akt的pleckstrin homology (PH)区。
More
