Integrin


Integrins are transmembrane receptors that are the bridges for cell-cell and cell-extracellular matrix (ECM) interactions. When triggered, integrins trigger chemical pathways to the interior (signal transduction). This results in a response (activation of transcription) like the regulation of the cell cycle, cell shape, and/or motility; or new receptors being added to the cell membrane. This allows rapid and flexible responses to events at the cell surface, for example to signal platelets to initiate an interaction with coagulation factors.
Integrins are obligate heterodimers, meaning that they have two different chains: the α (alpha) and β (beta) subunits.
Integrins work alongside other receptors such as cadherins, the immunoglobulin superfamily cell adhesion molecules, selectins and syndecans to mediate cell–cell and cell–matrix interaction. Ligands for integrins include fibronectin, vitronectin, collagen, and laminin.
  • GR 144053 trihydrochloride EI1219

    GR 144053 trihydrochloride是Glycoprotein IIb/IIIa (integrin αIIbβ3) 受体 拮抗剂。 抗血栓活性。

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  • BTT 3033 EI0637

    BTT 3033是整合蛋白 α2β1的选择性抑制剂。

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  • BIO 5192 EI0580

    BIO 5192是整合蛋白 α4β1的高活性的选择性抑制剂。

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  • GLPG0187 EY2848

    GLPG0187是广谱的integrin受体拮抗剂,具有抗肿瘤活性;抑制αvβ1-integrin的IC50值为1.3 nM。

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  • Cilengitide EY1634

    Cilengitide是一种有效的integrin(整合素)抑制剂,作用于αvβ3受体和αvβ5受体,IC50分别为4.1 nM和79 nM,比作用于gpIIbIIIa选择性高10倍左右。

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  • GR 144053 trihydrochloride EI1219

    GR 144053 trihydrochloride是Glycoprotein IIb/IIIa (integrin αIIbβ3) 受体 拮抗剂。 抗血栓活性。

    More
  • BTT 3033 EI0637

    BTT 3033是整合蛋白 α2β1的选择性抑制剂。

    More
  • BIO 5192 EI0580

    BIO 5192是整合蛋白 α4β1的高活性的选择性抑制剂。

    More
  • GLPG0187 EY2848

    GLPG0187是广谱的integrin受体拮抗剂,具有抗肿瘤活性;抑制αvβ1-integrin的IC50值为1.3 nM。

    More
  • Cilengitide EY1634

    Cilengitide是一种有效的integrin(整合素)抑制剂,作用于αvβ3受体和αvβ5受体,IC50分别为4.1 nM和79 nM,比作用于gpIIbIIIa选择性高10倍左右。

    More
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