CCR


There have been 20 distinct chemokine receptors discovered in humans. Each has a 7-transmembrane (7TM) structure and couples to G-protein for signal transduction within a cell, making them members of a large protein family of G protein-coupled receptors. CCR(Chemokine receptors) are cytokine receptors found on the surface of certain cells that interact with a type of cytokine called a chemokine.  Following interaction with their specific chemokine ligands, chemokine receptors trigger a flux in intracellular calcium (Ca2+) ions (calcium signaling). This causes cell responses, including the onset of a process known as chemotaxis that traffics the cell to a desired location within the organism. Chemokine receptors are divided into different families, CXC chemokine receptors, CC chemokine receptors, CX3C chemokine receptors and XC chemokine receptors that correspond to the 4 distinct subfamilies of chemokines they bind. Four families of chemokine receptors differ in spacing of cysteine residues near N-terminal of the receptor.
  • Maraviroc EY1740

    Maraviroc是一种趋化因子受体CCR5抑制剂,作用于MIP-1α, MIP-1β和RANTES 时,IC50分别为3.3 nM, 7.2 nM和5.2 nM。

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  • Maraviroc EY1740

    Maraviroc是一种趋化因子受体CCR5抑制剂,作用于MIP-1α, MIP-1β和RANTES 时,IC50分别为3.3 nM, 7.2 nM和5.2 nM。

    More
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