c-RET
The RET proto-oncogene encodes a receptor tyrosine kinase for members of the glial cell line-derived neurotrophic factor (GDNF) family of extracellular signalling molecules. RET proto-oncogene has been shown to interact with DOK1,DOK5,GDNF family receptor alpha 1,GRB10,GRB7,Grb2,SHC1 and STAT3.
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Regorafenib (瑞格非尼; BAY 73-4506) 是多靶点抑制剂,对VEGFR1,VEGFR2,VEGFR3,PDGFRβ,Kit,RET和Raf-1的IC50分别为13 nM,4.2 nM,46 nM,22 nM,7 nM,1.5 nM和2.5 nM。
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Regorafenib (瑞格非尼; BAY 73-4506) 是多靶点抑制剂,对VEGFR1,VEGFR2,VEGFR3,PDGFRβ,Kit,RET和Raf-1的IC50分别为13 nM,4.2 nM,46 nM,22 nM,7 nM,1.5 nM和2.5 nM。
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