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KEAP1-Nrf2


Nrf2 is a transcription factor that in humans is encoded by the NFE2L2 gene. Nrf2 is a basic leucine zipper (bZIP) protein that regulates the expression of antioxidant proteins that protect against oxidative damage triggered by injury and inflammation. Keap1 has been shown to interact with Nrf2, a master regulator of the antioxidant response, which is important for the amelioration of oxidative stress.Under quiescent conditions, Nrf2 is anchored in the cytoplasm through binding to Keap1, which, in turn, facilitates the ubiquitination and subsequent proteolysis of Nrf2. Such sequestration and further degradation of Nrf2 in the cytoplasm are mechanisms for the repressive effects of Keap1 on Nrf2.Because Nrf2 activation leads to a coordinated antioxidant and anti-inflammatory response, and Keap1 represses Nrf2 activation, Keap1 has become a very attractive drug target.
  • CDDO Im EI0720

    CDDO Im是Nrf2 信号通路激动剂。

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  • RA 839 EI2306

    RA 839是Nrf2 激动剂, 抑制 Nrf2/Keap1之间的相互作用。。

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  • Oltipraz EI2005

    Oltipraz是Nrf2 激动剂。

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  • NK 252 EI1895

    NK 252是Nrf2 激动剂。

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  • Dimethyl Fumarate EY1236

    Dimethyl fumarate是Nrf2通路活化剂。

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  • CDDO Im EI0720

    CDDO Im是Nrf2 信号通路激动剂。

    More
  • RA 839 EI2306

    RA 839是Nrf2 激动剂, 抑制 Nrf2/Keap1之间的相互作用。。

    More
  • Oltipraz EI2005

    Oltipraz是Nrf2 激动剂。

    More
  • NK 252 EI1895

    NK 252是Nrf2 激动剂。

    More
  • Dimethyl Fumarate EY1236

    Dimethyl fumarate是Nrf2通路活化剂。

    More
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