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Survivin


Survivin, also called baculoviral inhibitor of apoptosis repeat-containing 5 or BIRC5, is a protein that, in humans, is encoded by the BIRC5 gene.Survivin is a member of the inhibitor of apoptosis (IAP) family. The survivin protein functions to inhibit caspase activation, thereby leading to negative regulation of apoptosis or programmed cell death. 

  • YM155 EY0758

    YM155 (Sepantronium Bromide)是一种有效的survivin抑制剂，通过抑制Survivin启动子活性而发挥作用，IC50为0.54 nM；对SV40启动子活性抑制作用不显著，对Survivin与XIAP相互作用抑制效果微弱。Phase 1/2。

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