p53
Tumor protein p53, also known as p53, cellular tumor antigen p53 (UniProt name), phosphoprotein p53, tumor suppressor p53, antigen NY-CO-13, or transformation-related protein 53 (TRP53), is any isoform of a protein encoded by homologous genes in various organisms, such as TP53 (humans) and Trp53 (mice). This homolog is crucial in multicellular organisms, where it prevents cancer formation, thus, functions as a tumor suppressor. p53 has many mechanisms of anticancer function and plays a role in apoptosis, genomic stability, and inhibition of angiogenesis.
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HLI 373是Hdm2 抑制剂，激活p53-dependent transcription。
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CP 31398 dihydrochloride是p53稳定剂。
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SJ 172550是MDMX 抑制剂。 扰乱 MDMX-p53 之间的相互作用。。
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SCH 529074是SCH 529074 restores mutant p53 activity。
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RETRA hydrochloride是抗肿瘤活性，可以抑制 mutant p53-bearing 肿瘤细胞。
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