HDAC


HDAC (Histone deacetylases) are a class of enzymes that remove acetyl groups (O=C-CH3) from an ε-N-acetyl lysine amino acid on a histone, allowing the histones to wrap the DNA more tightly. This is important because DNA is wrapped around histones, and DNA expression is regulated by acetylation and de-acetylation. Its action is opposite to that of histone acetyltransferase. HDACs, are classified in four classes depending on sequence homology to the yeast original enzymes and domain organization:class I (HDAC1, HDAC2, HDAC3 and HDAC8), class II (HDAC4, HDAC5, HDAC7 and HDAC9) and class IV (HDAC11).
  • Quisinostat EY2222

    Quisinostat (JNJ-26481585) is a novel second-generation HDACi inhibitor with highest potency for HDAC1 with IC50 of 0.11 nM, modest potent to HDACs 2, 4, 10, and 11; greater than 30-fold selectivity against HDACs 3, 5, 8, and 9 and lowest potency to HDACs 6 and 7. , in NSCLC cells. In vitro, quisinostat has shown anti-proliferative activity against NSCLC cell lines. quisinostat extremely changed protein acetylation patterns of A549 cells and inhibited epithelial-mesenchymal transition (EMT) process.

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  • Apicidin EI0468

    Apicidin是活性的HDAC (histone deacetylase) 抑制剂。

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  • UF 010 EI2854

    UF 010是Class I HDAC 抑制剂。

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  • TCS HDAC6 20b EI2738

    TCS HDAC6 20b是选择性 HDAC6 抑制剂。

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  • TC-H 106 EI2709

    TC-H 106是Class I histone deacetylase(HDAC) 抑制剂。

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  • Quisinostat EY2222

    Quisinostat (JNJ-26481585) is a novel second-generation HDACi inhibitor with highest potency for HDAC1 with IC50 of 0.11 nM, modest potent to HDACs 2, 4, 10, and 11; greater than 30-fold selectivity against HDACs 3, 5, 8, and 9 and lowest potency to HDACs 6 and 7. , in NSCLC cells. In vitro, quisinostat has shown anti-proliferative activity against NSCLC cell lines. quisinostat extremely changed protein acetylation patterns of A549 cells and inhibited epithelial-mesenchymal transition (EMT) process.

    More
  • Apicidin EI0468

    Apicidin是活性的HDAC (histone deacetylase) 抑制剂。

    More
  • UF 010 EI2854

    UF 010是Class I HDAC 抑制剂。

    More
  • TCS HDAC6 20b EI2738

    TCS HDAC6 20b是选择性 HDAC6 抑制剂。

    More
  • TC-H 106 EI2709

    TC-H 106是Class I histone deacetylase(HDAC) 抑制剂。

    More
  • Quisinostat EY2222

    Quisinostat (JNJ-26481585) is a novel second-generation HDACi inhibitor with highest potency for HDAC1 with IC50 of 0.11 nM, modest potent to HDACs 2, 4, 10, and 11; greater than 30-fold selectivity against HDACs 3, 5, 8, and 9 and lowest potency to HDACs 6 and 7. , in NSCLC cells. In vitro, quisinostat has shown anti-proliferative activity against NSCLC cell lines. quisinostat extremely changed protein acetylation patterns of A549 cells and inhibited epithelial-mesenchymal transition (EMT) process.

    More
  • Apicidin EI0468

    Apicidin是活性的HDAC (histone deacetylase) 抑制剂。

    More
  • UF 010 EI2854

    UF 010是Class I HDAC 抑制剂。

    More
  • TCS HDAC6 20b EI2738

    TCS HDAC6 20b是选择性 HDAC6 抑制剂。

    More
  • TC-H 106 EI2709

    TC-H 106是Class I histone deacetylase(HDAC) 抑制剂。

    More
  • Quisinostat EY2222

    Quisinostat (JNJ-26481585) is a novel second-generation HDACi inhibitor with highest potency for HDAC1 with IC50 of 0.11 nM, modest potent to HDACs 2, 4, 10, and 11; greater than 30-fold selectivity against HDACs 3, 5, 8, and 9 and lowest potency to HDACs 6 and 7. , in NSCLC cells. In vitro, quisinostat has shown anti-proliferative activity against NSCLC cell lines. quisinostat extremely changed protein acetylation patterns of A549 cells and inhibited epithelial-mesenchymal transition (EMT) process.

    More
  • Apicidin EI0468

    Apicidin是活性的HDAC (histone deacetylase) 抑制剂。

    More
  • UF 010 EI2854

    UF 010是Class I HDAC 抑制剂。

    More
  • TCS HDAC6 20b EI2738

    TCS HDAC6 20b是选择性 HDAC6 抑制剂。

    More
  • TC-H 106 EI2709

    TC-H 106是Class I histone deacetylase(HDAC) 抑制剂。

    More
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